Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Oxotremorine sesquifumarate 是一种毒蕈碱受体激动剂,对 M2 的激活作用更强,可用于神经学研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 197 | 现货 | ||
5 mg | ¥ 371 | 现货 | ||
10 mg | ¥ 556 | 现货 | ||
25 mg | ¥ 951 | 现货 | ||
50 mg | ¥ 1,290 | 现货 | ||
100 mg | ¥ 1,930 | 现货 |
产品描述 | Oxotremorine sesquifumarate is a muscarinic receptor agonist. |
体外活性 | Oxotremorine (10.5 micron) produced a paralytic effect on twitch responses of rat diaphragm in vitro to direct and indirect stimulation[1]. |
体内活性 | Rats with signs of neuropathy were subjected to SCS applied in awake, freely moving condition. Oxotremorine was administered intrathecally. Tactile, cold and heat sensitivities were assessed by using von Frey filaments, cold spray and focused radiant heat, respectively. Oxotremorine i.t. dose-dependently suppressed the tactile hypersensitivity. SCS markedly increased withdrawal thresholds (WTs), withdrawal latencies and cold scores[2]. |
分子量 | 380.4 |
分子式 | C12H18N2O·1·5C4H4O4 |
CAS No. | 17360-35-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (144.58 mM)
H2O: < 8 mg/mL (21.03 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / H2O | 1 mM | 2.6288 mL | 13.1441 mL | 26.2881 mL | 65.7203 mL |
5 mM | 0.5258 mL | 2.6288 mL | 5.2576 mL | 13.1441 mL | |
10 mM | 0.2629 mL | 1.3144 mL | 2.6288 mL | 6.572 mL | |
20 mM | 0.1314 mL | 0.6572 mL | 1.3144 mL | 3.286 mL | |
DMSO | 50 mM | 0.0526 mL | 0.2629 mL | 0.5258 mL | 1.3144 mL |
100 mM | 0.0263 mL | 0.1314 mL | 0.2629 mL | 0.6572 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Oxotremorine sesquifumarate 17360-35-9 Neuroscience AChR Inhibitor mAChR inhibit tremorogenic neurological Muscarinic acetylcholine receptor inhibitor